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Central African Republic Travel Health Guide

High risk

Central African Republic carries a CDC Level 2 travel health notice. Malaria risk exists throughout Central African Republic. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.

Overall risk

High risk

Malaria

Present

Best time to visit

Year-round

Recommended vaccines

Routine Vaccines

Make sure you are up-to-date on all routine vaccines including chickenpox, diphtheria-tetanus-pertussis, flu, measles-mumps-rubella, polio, and shingles.

Recommended

COVID-19

All eligible travelers should be up to date with their COVID-19 vaccines.

Recommended

Hepatitis A

Hepatitis A vaccine is recommended for all unvaccinated travelers one year and older. Infants 6-11 months should also be vaccinated.

Recommended

Hepatitis B

Hepatitis B vaccine is recommended for all unvaccinated travelers of any age going to Central African Republic.

Recommended

Measles

All international travelers should be fully vaccinated against measles with MMR vaccine, including early doses for infants 6-11 months.

Recommended

Polio

Polio vaccine is recommended as poliovirus has been identified in Central African Republic. Adults may need a booster dose, unvaccinated travelers need complete series.

Recommended

Typhoid

Typhoid vaccine is recommended for most travelers, especially if staying with friends/relatives or visiting smaller cities or rural areas.

Recommended

Yellow Fever

Yellow fever vaccine is both recommended by CDC and required for entry into Central African Republic for all travelers 9 months and older.

Recommended

Cholera

Cholera vaccine is not recommended as there is no longer active cholera transmission in Central African Republic.

Situational

Meningococcal Disease

Meningococcal vaccine is recommended for travelers 2 months and older going to meningitis belt areas during dry season (December to June).

Situational

Monkeypox

Monkeypox vaccine is recommended for people planning high-risk sexual activities. Get first dose at least 6 weeks before travel if possible.

Situational

Rabies

Rabies pre-exposure vaccination should be considered based on your planned activities and access to medical care. Rabid dogs are commonly found in Central African Republic.

Situational

Disease risks

Malaria risk

Malaria is present in this destination. Prophylaxis medication is recommended.

Malaria risk exists throughout Central African Republic. CDC recommends taking prescription antimalarial medication. P. falciparum is the primary species and chloroquine resistance is present.

Emergency numbers

Police

117

Medical / Ambulance

118

Fire

118

U.S. Embassy

+234-9-461-4000

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Sources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.