Central African Republic Travel Health Guide
High risk
Central African Republic carries a CDC Level 2 travel health notice. Malaria risk exists throughout Central African Republic. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Overall risk
High risk
Malaria
Present
Best time to visit
Year-round
Recommended vaccines
Routine Vaccines
Make sure you are up-to-date on all routine vaccines including chickenpox, diphtheria-tetanus-pertussis, flu, measles-mumps-rubella, polio, and shingles.
COVID-19
All eligible travelers should be up to date with their COVID-19 vaccines.
Hepatitis A
Hepatitis A vaccine is recommended for all unvaccinated travelers one year and older. Infants 6-11 months should also be vaccinated.
Hepatitis B
Hepatitis B vaccine is recommended for all unvaccinated travelers of any age going to Central African Republic.
Measles
All international travelers should be fully vaccinated against measles with MMR vaccine, including early doses for infants 6-11 months.
Polio
Polio vaccine is recommended as poliovirus has been identified in Central African Republic. Adults may need a booster dose, unvaccinated travelers need complete series.
Typhoid
Typhoid vaccine is recommended for most travelers, especially if staying with friends/relatives or visiting smaller cities or rural areas.
Yellow Fever
Yellow fever vaccine is both recommended by CDC and required for entry into Central African Republic for all travelers 9 months and older.
Cholera
Cholera vaccine is not recommended as there is no longer active cholera transmission in Central African Republic.
Meningococcal Disease
Meningococcal vaccine is recommended for travelers 2 months and older going to meningitis belt areas during dry season (December to June).
Monkeypox
Monkeypox vaccine is recommended for people planning high-risk sexual activities. Get first dose at least 6 weeks before travel if possible.
Rabies
Rabies pre-exposure vaccination should be considered based on your planned activities and access to medical care. Rabid dogs are commonly found in Central African Republic.
Disease risks
Malaria
Malaria risk exists throughout Central African Republic. CDC recommends taking prescription antimalarial medication. P. falciparum is the primary species and chloroquine resistance is present.
Traveler's Diarrhea
All areas; poor sanitation widespread.
Malaria risk
Malaria is present in this destination. Prophylaxis medication is recommended.
Malaria risk exists throughout Central African Republic. CDC recommends taking prescription antimalarial medication. P. falciparum is the primary species and chloroquine resistance is present.
Emergency numbers
Police
117
Medical / Ambulance
118
Fire
118
U.S. Embassy
+234-9-461-4000
More country guides
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Build my Trip KitSources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.