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Djibouti Travel Health Guide

High risk

Djibouti carries a CDC Level 2 travel health notice. Malaria risk exists throughout Djibouti. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B. Yellow fever vaccination not needed for disease protection but required for entry if traveling from countries with yellow fever risk, including airport layovers over 12 hours.

Overall risk

High risk

Malaria

Present

Best time to visit

Year-round

Recommended vaccines

Routine Vaccines

Make sure all routine vaccinations are current before travel, including chickenpox, tetanus, flu, MMR, polio, and shingles vaccines.

Recommended

COVID-19

Stay up to date with COVID-19 vaccinations before traveling.

Recommended

Hepatitis A

Hepatitis A vaccination recommended for all unvaccinated travelers over 1 year old. Special dosing for infants and high-risk travelers.

Recommended

Hepatitis B

Hepatitis B vaccination recommended for all unvaccinated travelers regardless of age.

Recommended

Measles

MMR vaccination required for all travelers due to rising measles cases worldwide. Infants 6-11 months need early vaccination.

Recommended

Polio

Polio vaccination essential due to poliovirus presence in Djibouti. Adults may need booster shot, unvaccinated travelers need complete series.

Recommended

Typhoid

Typhoid vaccination recommended, especially if visiting rural areas or staying with local families.

Recommended

Chikungunya

Vaccination not generally recommended - focus on preventing mosquito bites instead.

Situational

Rabies

Consider rabies vaccination if you'll be around animals or in rural areas where treatment may not be readily available.

Situational

Yellow Fever

Yellow fever vaccination not needed for disease protection but required for entry if traveling from countries with yellow fever risk, including airport layovers over 12 hours.

Situational

Disease risks

Malaria risk

Malaria is present in this destination. Prophylaxis medication is recommended.

Malaria risk exists throughout Djibouti. Prescription antimalarial medication is recommended for all travelers. Chloroquine-resistant malaria is present.

Emergency numbers

Police

17

Medical / Ambulance

18

Fire

18

U.S. Embassy

+253-21-453-000

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Sources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.