Djibouti Travel Health Guide
High risk
Djibouti carries a CDC Level 2 travel health notice. Malaria risk exists throughout Djibouti. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B. Yellow fever vaccination not needed for disease protection but required for entry if traveling from countries with yellow fever risk, including airport layovers over 12 hours.
Overall risk
High risk
Malaria
Present
Best time to visit
Year-round
Recommended vaccines
Routine Vaccines
Make sure all routine vaccinations are current before travel, including chickenpox, tetanus, flu, MMR, polio, and shingles vaccines.
COVID-19
Stay up to date with COVID-19 vaccinations before traveling.
Hepatitis A
Hepatitis A vaccination recommended for all unvaccinated travelers over 1 year old. Special dosing for infants and high-risk travelers.
Hepatitis B
Hepatitis B vaccination recommended for all unvaccinated travelers regardless of age.
Measles
MMR vaccination required for all travelers due to rising measles cases worldwide. Infants 6-11 months need early vaccination.
Polio
Polio vaccination essential due to poliovirus presence in Djibouti. Adults may need booster shot, unvaccinated travelers need complete series.
Typhoid
Typhoid vaccination recommended, especially if visiting rural areas or staying with local families.
Chikungunya
Vaccination not generally recommended - focus on preventing mosquito bites instead.
Rabies
Consider rabies vaccination if you'll be around animals or in rural areas where treatment may not be readily available.
Yellow Fever
Yellow fever vaccination not needed for disease protection but required for entry if traveling from countries with yellow fever risk, including airport layovers over 12 hours.
Disease risks
Malaria risk
Malaria is present in this destination. Prophylaxis medication is recommended.
Malaria risk exists throughout Djibouti. Prescription antimalarial medication is recommended for all travelers. Chloroquine-resistant malaria is present.
Emergency numbers
Police
17
Medical / Ambulance
18
Fire
18
U.S. Embassy
+253-21-453-000
More country guides
British Indian Ocean Territory carries a CDC Level 1 travel health notice. No malaria risk. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Burundi carries a CDC Level 1 travel health notice. Malaria risk exists throughout Burundi year-round. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Comoros carries a CDC Level 1 travel health notice. Malaria risk exists throughout Comoros. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
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Build my Trip KitSources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.