Low riskEurope · Southern EuropeHoly See (Vatican City State) Travel Health Guide
Low risk
Holy See (Vatican City State) carries a CDC Level 1 travel health notice. No malaria risk. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Overall risk
Low risk
Malaria
None
Best time to visit
Year-round
Recommended vaccines
Routine Vaccines
Make sure you're up-to-date on all routine vaccines including chickenpox, tetanus, flu, MMR, polio, and shingles.
COVID-19
Stay up-to-date with COVID-19 vaccines before traveling.
Hepatitis A
Consider hepatitis A vaccine if visiting smaller cities, rural areas, or eating street food.
Hepatitis B
Hepatitis B vaccine is recommended for unvaccinated travelers under 60, and may be considered for those 60 and older.
Measles
Measles cases are rising worldwide. All travelers need MMR vaccine at least 2 weeks before travel. Infants 6-11 months need an early dose.
Rabies
Rabid dogs are uncommon in Italy. Rabies vaccines are available if needed. Consider pre-exposure vaccination only if you'll have high-risk animal exposure or limited access to medical care.
Tick-borne Encephalitis
TBE vaccine is recommended if you'll have extensive outdoor activities with tick exposure in endemic areas of Italy.
Yellow Fever
Yellow fever vaccine is not recommended and not required for entry to Italy.
Disease risks
Emergency numbers
Police
112
Medical / Ambulance
118
Fire
115
U.S. Embassy
+39-06-4674-3428
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Build my Trip KitSources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.