Sao Tome and Principe Travel Health Guide
High risk
Sao Tome and Principe carries a CDC Level 1 travel health notice. Malaria risk exists throughout São Tomé and Príncipe. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Overall risk
High risk
Malaria
Present
Best time to visit
Year-round
Recommended vaccines
Routine Vaccines
Make sure all your routine vaccines are current, including chickenpox, tetanus, flu, MMR, polio, and shingles vaccines.
COVID-19
Stay up to date with COVID-19 vaccines before traveling.
Hepatitis A
Hepatitis A vaccine is recommended for all travelers to São Tomé and Príncipe, including infants 6-11 months old.
Hepatitis B
Hepatitis B vaccine is recommended for all unvaccinated travelers regardless of age.
Measles
Measles cases are rising worldwide. Make sure you're fully vaccinated with MMR vaccine at least 2 weeks before travel, including early vaccination for infants 6-11 months.
Typhoid
Typhoid vaccine is recommended for most travelers, especially if you're staying with friends/family or visiting smaller cities or rural areas.
Rabies
Rabid dogs are commonly found in São Tomé and Príncipe. Consider pre-exposure rabies vaccination if you'll be around animals or in areas where medical care may be limited.
Yellow Fever
Yellow fever vaccine is generally not recommended for São Tomé and Príncipe, but is required if you're coming from a country with yellow fever risk or have a long layover in such countries.
Disease risks
Malaria risk
Malaria is present in this destination. Prophylaxis medication is recommended.
Malaria risk exists throughout São Tomé and Príncipe. Take antimalarial medication as prescribed, starting before your trip and continuing during and after. The malaria parasites are resistant to chloroquine.
Emergency numbers
Police
222
Medical / Ambulance
222
Fire
112
U.S. Embassy
+239-222-3709
More country guides
Angola carries a CDC Level 2 travel health notice. Malaria risk exists throughout Angola. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Cameroon carries a CDC Level 2 travel health notice. Malaria risk exists throughout Cameroon year-round. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Central African Republic carries a CDC Level 2 travel health notice. Malaria risk exists throughout Central African Republic. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
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Build my Trip KitSources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.