ST flagHigh riskAfrica · Middle Africa

Sao Tome and Principe Travel Health Guide

High risk

Sao Tome and Principe carries a CDC Level 1 travel health notice. Malaria risk exists throughout São Tomé and Príncipe. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.

Overall risk

High risk

Malaria

Present

Best time to visit

Year-round

Recommended vaccines

Routine Vaccines

Make sure all your routine vaccines are current, including chickenpox, tetanus, flu, MMR, polio, and shingles vaccines.

Recommended

COVID-19

Stay up to date with COVID-19 vaccines before traveling.

Recommended

Hepatitis A

Hepatitis A vaccine is recommended for all travelers to São Tomé and Príncipe, including infants 6-11 months old.

Recommended

Hepatitis B

Hepatitis B vaccine is recommended for all unvaccinated travelers regardless of age.

Recommended

Measles

Measles cases are rising worldwide. Make sure you're fully vaccinated with MMR vaccine at least 2 weeks before travel, including early vaccination for infants 6-11 months.

Recommended

Typhoid

Typhoid vaccine is recommended for most travelers, especially if you're staying with friends/family or visiting smaller cities or rural areas.

Recommended

Rabies

Rabid dogs are commonly found in São Tomé and Príncipe. Consider pre-exposure rabies vaccination if you'll be around animals or in areas where medical care may be limited.

Situational

Yellow Fever

Yellow fever vaccine is generally not recommended for São Tomé and Príncipe, but is required if you're coming from a country with yellow fever risk or have a long layover in such countries.

Situational

Disease risks

Malaria risk

Malaria is present in this destination. Prophylaxis medication is recommended.

Malaria risk exists throughout São Tomé and Príncipe. Take antimalarial medication as prescribed, starting before your trip and continuing during and after. The malaria parasites are resistant to chloroquine.

Emergency numbers

Police

222

Medical / Ambulance

222

Fire

112

U.S. Embassy

+239-222-3709

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Sources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.