ZA flagModerate riskAfrica · Southern Africa

South Africa Travel Health Guide

Moderate risk

South Africa carries a CDC Level 1 travel health notice. Malaria risk exists in certain border areas and provinces of South Africa. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B. Yellow fever vaccine is not needed if traveling directly from the US, but is required if you're coming from a country with yellow fever risk or have a long layover in such countries.

Overall risk

Moderate risk

Malaria

Present

Best time to visit

Year-round

Recommended vaccines

Routine Vaccines

Make sure all your routine vaccines are up to date, including chickenpox, tetanus, flu, MMR, polio, and shingles vaccines.

Recommended

COVID-19

Stay up to date with COVID-19 vaccines before traveling.

Recommended

Hepatitis A

Hepatitis A vaccine is recommended for most travelers to South Africa, including infants 6-11 months old.

Recommended

Hepatitis B

Hepatitis B vaccine is recommended for travelers under 60 and may be considered for those 60 and older.

Recommended

Measles

Measles cases are rising worldwide. Make sure you're fully vaccinated with MMR vaccine at least 2 weeks before travel, including infants 6-11 months.

Recommended

Typhoid

Typhoid vaccine is recommended for most travelers to South Africa, especially if visiting rural areas or staying with friends and relatives.

Recommended

Cholera

Cholera vaccine is not needed for South Africa as there is no active transmission.

Situational

Rabies

Rabies is present in dogs and wildlife in South Africa. Consider pre-exposure vaccination if you'll be around animals or in remote areas. Vaccines are available in most of the country if needed after exposure.

Situational

Yellow Fever

Yellow fever vaccine is not needed if traveling directly from the US, but is required if you're coming from a country with yellow fever risk or have a long layover in such countries.

Situational

Disease risks

Malaria risk

Malaria is present in this destination. Prophylaxis medication is recommended.

Malaria risk exists in certain border areas and provinces of South Africa. Antimalarial medication is recommended for high-risk areas including parts of KwaZulu-Natal, Limpopo, Mpumalanga provinces, and Kruger National Park. In lower-risk areas, only mosquito bite prevention is recommended.

Emergency numbers

Police

10111

Medical / Ambulance

10177

Fire

10177

U.S. Embassy

+27-21-702-7300

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Sources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.