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South Sudan Travel Health Guide

High risk

South Sudan carries a CDC Level 2 travel health notice. Malaria risk exists throughout South Sudan. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.

Overall risk

High risk

Malaria

Present

Best time to visit

Year-round

Recommended vaccines

Routine Vaccines

Make sure you are up-to-date on all routine vaccines including chickenpox, DTP, flu, MMR, polio, and shingles before traveling.

Recommended

COVID-19

Stay up to date with COVID-19 vaccines before traveling.

Recommended

Hepatitis A

Get hepatitis A vaccine if you haven't been vaccinated. Infants 6-11 months should also get vaccinated.

Recommended

Hepatitis B

Get hepatitis B vaccine if you haven't been vaccinated, regardless of your age.

Recommended

Measles

Get MMR vaccine at least 2 weeks before travel. Infants 6-11 months should get an early dose.

Recommended

Polio

Polio vaccine is important as poliovirus has been found in South Sudan. Adults may need a booster; unvaccinated travelers need the complete vaccine series.

Recommended

Typhoid

Get typhoid vaccine, especially if staying with friends/relatives or visiting smaller cities or rural areas.

Recommended

Yellow Fever

Yellow fever vaccine is both recommended and required for entry to South Sudan for all travelers 9 months and older.

Recommended

Cholera

Cholera vaccination may be recommended for some travelers as there is widespread active cholera transmission in South Sudan. Practice good food and water safety.

Situational

Meningococcal Disease

Get meningococcal vaccine if traveling to meningitis belt areas of South Sudan during dry season (December-June).

Situational

Monkeypox

Monkeypox vaccine is recommended if you plan certain high-risk activities. Get vaccinated at least 6 weeks before travel if possible.

Situational

Rabies

Consider rabies vaccine before travel as infected dogs are common and treatment may be hard to find. Consult with a healthcare provider about pre-exposure vaccination.

Situational

Disease risks

Malaria risk

Malaria is present in this destination. Prophylaxis medication is recommended.

Malaria risk exists throughout South Sudan. Take prescription antimalarial medication as recommended by your doctor. Start taking medication before your trip and continue during and after your trip.

Emergency numbers

Police

777

Medical / Ambulance

777

Fire

777

U.S. Embassy

+211-912-105-188

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Sources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.