South Sudan Travel Health Guide
High risk
South Sudan carries a CDC Level 2 travel health notice. Malaria risk exists throughout South Sudan. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Overall risk
High risk
Malaria
Present
Best time to visit
Year-round
Recommended vaccines
Routine Vaccines
Make sure you are up-to-date on all routine vaccines including chickenpox, DTP, flu, MMR, polio, and shingles before traveling.
COVID-19
Stay up to date with COVID-19 vaccines before traveling.
Hepatitis A
Get hepatitis A vaccine if you haven't been vaccinated. Infants 6-11 months should also get vaccinated.
Hepatitis B
Get hepatitis B vaccine if you haven't been vaccinated, regardless of your age.
Measles
Get MMR vaccine at least 2 weeks before travel. Infants 6-11 months should get an early dose.
Polio
Polio vaccine is important as poliovirus has been found in South Sudan. Adults may need a booster; unvaccinated travelers need the complete vaccine series.
Typhoid
Get typhoid vaccine, especially if staying with friends/relatives or visiting smaller cities or rural areas.
Yellow Fever
Yellow fever vaccine is both recommended and required for entry to South Sudan for all travelers 9 months and older.
Cholera
Cholera vaccination may be recommended for some travelers as there is widespread active cholera transmission in South Sudan. Practice good food and water safety.
Meningococcal Disease
Get meningococcal vaccine if traveling to meningitis belt areas of South Sudan during dry season (December-June).
Monkeypox
Monkeypox vaccine is recommended if you plan certain high-risk activities. Get vaccinated at least 6 weeks before travel if possible.
Rabies
Consider rabies vaccine before travel as infected dogs are common and treatment may be hard to find. Consult with a healthcare provider about pre-exposure vaccination.
Disease risks
Malaria
Malaria risk exists throughout South Sudan. Take prescription antimalarial medication as recommended by your doctor. Start taking medication before your trip and continue during and after your trip.
Traveler's Diarrhea
All areas; extreme sanitation challenges.
Malaria risk
Malaria is present in this destination. Prophylaxis medication is recommended.
Malaria risk exists throughout South Sudan. Take prescription antimalarial medication as recommended by your doctor. Start taking medication before your trip and continue during and after your trip.
Emergency numbers
Police
777
Medical / Ambulance
777
Fire
777
U.S. Embassy
+211-912-105-188
More country guides
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Burundi carries a CDC Level 1 travel health notice. Malaria risk exists throughout Burundi year-round. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
Comoros carries a CDC Level 1 travel health notice. Malaria risk exists throughout Comoros. Key travel vaccines: COVID-19, Hepatitis A, Hepatitis B.
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Build my Trip KitSources: CDC Travelers' Health · WHO International Travel and Health. Last updated 2026-07-31. Health conditions and entry rules change — verify with the CDC, WHO and your destination’s authorities before travel. This page is informational and not a substitute for advice from a travel-medicine provider.